association between the severity of angiographic coronary artery disease and paraoxonase-1 promoter gene polymorphism t(-107)c in iranian population
نویسندگان
چکیده
the oxidation of low-density lipoproteins and cell membrane lipids is believed to play an integral role in the development of fatty streak lesions, an initial step in coronary artery disease (cad). paraoxonase-1 (pon1) is an enzyme associated with the high-density lipoprotein (hdl) particle. pon1 protects ldl from oxidative modification by hydrolyzing lipid peroxides, suggestive of a role for pon1 in the development of cad. the present study tested the hypothesis that paraoxonase-1 promoter polymorphism t(-107)c could be a risk factor for severity of cad in iranian population. paraoxonase-1 promoter genotypes were determined in 300 consecutive subjects (> 40 years old) who underwent coronary angiography (150 subjects with >50% stenosis served as cases [cad+] and 150 subjects with
منابع مشابه
association between paraoxonase -1 gene pro-moter t (-107) c polymorphism and coronary artery disease
background: paraoxonase-1(pon1), a high-density lipoprotein (hdl) associated enzyme, is believed to contribute in the pathogenesis of coronary artery disease (cad). the aim of this study was to evaluate the association of pon1 promoter c (-107)t polymorphism with the extent of coronary artery stenosis in iranian patients. methods : the rflp analysis for determination of the c(-107)t genotype d...
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عنوان ژورنال:
acta medica iranicaجلد ۴۶، شماره ۳، صفحات ۱۹۷-۲۰۲
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